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epote
(@epote)
New Member
Joined: 2 weeks ago
Posts: 4
 

to be honest, i tend to not like any drugs that mess with my brain too much.

i even despice caffeine.


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zuper
(@zuper)
New Member
Joined: 2 weeks ago
Posts: 3
 
Posted by: @SupremeDan
Remeron is shown to greatly decrease cortisol release through ACTH inhibition...anybody use it for post cycle allready???

seems as a great adition to a HCG/CLOMID/NOLVA/AROMASIN post cycle therapy to have the best posct cycle therapy ever!!!!!!!!

Go with Trittiko similar to remeron but not so much hungry and groggy the next day.
You can try also Dilantin anticonvusant clears cortisol off but only cortisol!!
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liorrh
(@liorrh)
Eminent Member
Joined: 2 months ago
Posts: 21
 
Posted by: @andr3as
well quite honestly said, it is due to 5ht2a blockade triggered by alpha2 antagonism

so.. how come yohimbine doesn't do that, being an alpha2 antagonsit? on the contrary, in decreases appetite


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andr3as
(@andr3as)
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Joined: 2 years ago
Posts: 4
 
Posted by: @liorrh
so.. how come yohimbine doesn't do that, being an alpha2 antagonsit? on the contrary, in decreases appetite

In contrary yohimbine and mirtazapine are not comparable. Although they effect similar systems their mechanism is different. Structually yohimbine does not bind to a2 receptors, rather enters the cell and inhibits a2 dependent NE vesicle formation.
Mirtazapine OTOH is a mild antipsychotic with antidepressive properties, without dopaminergic effect


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bigj
 bigj
(@bigj)
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Joined: 2 weeks ago
Posts: 1
 

mirtazapine is a godsend when my insomnia is out of control. Ambien...tried it, works sometimes, Lunesta....tried it, works sometimes..... This stuff works all the time, it does make you hungry, but it wasn't an "I CAN"T stop eating" type of hunger. If it was, I'd just take some meridia before bed-time and coast....


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Fecal McAngry
(@fecal-mcangry)
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Joined: 2 months ago
Posts: 3
 
Posted by: @Section 8
It's a tetracyclic anti-depressant. While not as bad as the tricyclics, there are still concerns re. hepatoxicity and cardiotoxicity to worry about. One of the other issues very relevant to the context being discussed is that it can royally fuck with lipids in some people. Moreover, immediate corisol control notwithstanding, you need to take into account the mechanism whereby cortisol is controlled. There will be a rebound following use, for one thing. Personally, I would be far more concerned about the mental effects in normal people. As stated, this is a bona-fide tetracyclic anti-depressant. They don't even prescribe this stuff to people with run of the mill depression. It's reserved for cases of dysthmic and other treatment resistant depressions, e.g. cases where treatment with SSRI's, including the more potent ones like prozac and paxil, have failed,

FWIW, Prozac is, IIRC, the least potent SSRI...

"I measure success by the degree to which I ruin other people's lives."
--Fecal McAngry--


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zuper
(@zuper)
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Posted by: @Fecal McAngry
FWIW, Prozac is, IIRC, the least potent SSRI...

What do you mean?


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Section 8
(@section-8)
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Joined: 1 year ago
Posts: 6
 
Posted by: @zuper
What do you mean?

What he means is that he's talking nonsense.


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Fecal McAngry
(@fecal-mcangry)
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Joined: 2 months ago
Posts: 3
 
Posted by: @zuper
What do you mean?

As far as inhibiting the reuptake of serotonin, fluoxetine is supposedly the weakest SSRI. I assume when the term "weakest" is used, the meaning is "least selective for serotonin" in the usual therapeutic dosages.

Of course, all of the SSRIs have different characteristics. Fluoxetine is much stronger than the other SSRIs at inhibiting the reuptake of norepinephrine, which makes it much more "activating" for most than the other SSRIs. And Paxil has unusually strong anticholinergic properties, which makes it a good choice for "skinny teenagers who can't stop fucking" to steal a pithy phrase (it increases appetite, sedates, and kills sex drive in many)...

"I measure success by the degree to which I ruin other people's lives."
--Fecal McAngry--


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Fecal McAngry
(@fecal-mcangry)
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Posted by: @Section 8
What he means is that he's talking nonsense.

Banshee omlet nose make marsupil creme testical zoom zoom? Meek, though L. Ron pungent dumpling climbing, climbing ME MAKE POOPIE!!!

"I measure success by the degree to which I ruin other people's lives."
--Fecal McAngry--


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zuper
(@zuper)
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Posts: 3
 
Posted by: @Fecal McAngry
Banshee omlet nose make marsupil creme testical zoom zoom? Meek, though L. Ron pungent dumpling climbing, climbing ME MAKE POOPIE!!!

And he is talking nonsense


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