6-OXO - Supplements

RE: 6-OXO

Jeff — Wed, 14 Aug 2019 21:00:39 +0000

I'm sure he will deny me of it. i haven't got the hormonal test yet. But i am sick of waiting, it is messing me up(the gyno). So i'm just going with it now.

RE: 6-OXO

davin8r — Wed, 14 Aug 2019 20:41:49 +0000

Posted by: @jm5913
Piperine extract is extremely cheap. Its often sold under the trade name bioprine. I dont know about using it though as there are some stuides showing it hurts the absorbtion of certain nutrients while it boosts others. If you wanted to give it a go though it would only cost you about 5 bucks for a months supply.

I pretty much scoured the literature, and only found positive studies involving bioperine (piperine) and nutrient absorption, no studies which found inhibition. Its other effect, at slightly higher doses, is inhibition of metabolism of various compounds by the liver, which serves to maintain higher blood levels of the nutrient/compound/drug.

This could be a good or a bad thing, depending on whatever kind of "supplement" a person takes with it.

RE: 6-OXO

TheIronSpud — Wed, 14 Aug 2019 20:18:45 +0000

I couldn't find the quote, but PA said that he's not going to guarantee that there won't be any contamination with Nor-precursors; I think that anyone that would guarantee it would be full of it anyhow. I really wouldn't worry about it. Unless you're getting really big really quick, nobody is going to want to pay to test you for steroids. Did the doc turn you down for Nolva?

RE: 6-OXO

Jeff — Wed, 14 Aug 2019 19:58:41 +0000

Can 6-OXO cause a false positive on a drug test?

RE: 6-OXO

Spook — Wed, 14 Aug 2019 19:30:37 +0000

Piperine extract is extremely cheap. Its often sold under the trade name bioprine. I dont know about using it though as there are some stuides showing it hurts the absorbtion of certain nutrients while it boosts others. If you wanted to give it a go though it would only cost you about 5 bucks for a months supply.

RE: 6-OXO

ChemicalPA — Wed, 14 Aug 2019 19:06:59 +0000

Posted by: @nightop
how does 6-oxo compare to perscription suicide aromatase inhibitors in terms of action and strength? Earlier in this thread we discussed the differences between suicide inhibitors and regular anti-aromatase drugs (i.e. arimidex or femara)... I'm not asking that again, rather... how is 6-oxo OTC if it is a true suicide inhibitor of comparable strength to perscription suicide inhibitors such as aromasin?

The active dosage of the 6-OXO is probably around 500mg a day. Obviously the active dose of something like aromasin is much lower. However, what matters is the cost per active dose. Therefore 6-OXO may compare very well to aromasin.

RE: 6-OXO

Par Deus — Wed, 14 Aug 2019 18:38:20 +0000

I made a chrysin topical in DMSO for several people, which worked quite well at lowering estrogen. Had blood tests to back it up. However, chrysin also inhibits 17-beta-HSD, which converts a-dione or a-diol to testosterone, so you would not want to use it unless you were on androgens, or had really high estrogen levels, naturally.

RE: 6-OXO

davin8r — Wed, 14 Aug 2019 18:19:37 +0000

Patrick or anyone else;

What do you think of the strategy used by the Life Extension Foundation to enhance bioavailability of chrysin? They pair it with piperine extract from black pepper, which according to several studies (see below) actually does increase the bioavailability of everything that's been tested with it.

2: Khajuria A, Thusu N, Zutshi U. Related Articles, Links

Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics.
Phytomedicine. 2002 Apr;9(3):224-31.
PMID: 12046863

3: Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Related Articles, Links

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
Planta Med. 1998 May;64(4):353-6.
PMID: 9619120

4: Khajuria A, Zutshi U, Bedi KL. Related Articles, Links

Permeability characteristics of piperine on oral absorption--an active alkaloid from peppers and a bioavailability enhancer.
Indian J Exp Biol. 1998 Jan;36(1):46-50.
PMID: 9536651

5: Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Related Articles, Links

Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers.
Eur J Clin Pharmacol. 1991;41(6):615-7.
PMID: 1815977

6: Bano G, Amla V, Raina RK, Zutshi U, Chopra CL. Related Articles, Links

The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers.
Planta Med. 1987 Dec;53(6):568-9. No abstract available.
PMID: 3444866

7: Atal CK, Zutshi U, Rao PG. Related Articles, Links

Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.
J Ethnopharmacol. 1981 Sep;4(2):229-32.
PMID: 7311598

RE: 6-OXO

androshack — Wed, 14 Aug 2019 17:52:05 +0000

back to the original question regarding 5-alpha.
Yes I would taper the 5-alpha for a week and use the 6-OXO or DIM and calcium glucarate.

Why?

In theory the 5-alpha (DHT) will block the estrogen built up in your system from your bodies herclucian effort to keep the androgen/estrogen ratio oh so perfect, from stimulating the estrogen receptor. The DIM and calcium glucarate help to metabolize the estrogen quicker as it frantically tries to find an open receptor and grow some nice boobs. If your lucky and taper down the 5-alpha right you should come out of your cycle with a desirable test/estrogen ratio and avoid a horrible estrogen rebound while increasing recovery. If your going to use Tribestan use it the last 2 weeks and in your taper, it is strong but is also suppresive if used too long as the increase in LH will send a signal to another feedback controll.

homeostatis sucks!

RE: 6-OXO

Par Deus — Wed, 14 Aug 2019 17:31:39 +0000

I should add that I did not mean to sound alarmist at all in my rebound post -- basically, if you stop cold turkey, just know that a rebound is possible and know what to look for (pre-gyno and such).

I assume the half-life of estrogen in the blood is not that long, so you could just start right up taking it again, if you had problems.