Pct - Pass The Wine  

  RSS

D Sade
(@d-sade)
New Member
Joined: 2 months ago
Posts: 2
09/09/2019 12:25 pm  

Cancer Res. 2006 Jun 1;66(11):5960-7. Related Articles, Links

Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.

Kijima I, Phung S, Hur G, Kwok SL, Chen S.

Department of Surgical Research, Beckman Research Institute of the City of Hope, Duarte, California, USA.

Aromatase is the enzyme that converts androgen to estrogen. It is expressed at higher levels in breast cancer tissues than normal breast tissues. Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In this study, GSE was found to inhibit aromatase activity in a dose-dependent manner and reduce androgen-dependent tumor growth in an aromatase-transfected MCF-7 (MCF-7aro) breast cancer xenograft model, agreeing with our previous findings. We have also examined the effect of GSE on aromatase expression. Reverse transcription-PCR experiments showed that treatment with 60 mug/mL of GSE suppressed the levels of exon I.3-, exon PII-, and exon I.6-containing aromatase mRNAs in MCF-7 and SK-BR-3 cells. The levels of exon I.1-containing mRNA, however, did not change with GSE treatment. Transient transfection experiments with luciferase-aromatase promoter I.3/II or I.4 reporter vectors showed the suppression of the promoter activity in a dose-dependent manner. The GSE treatment also led to the down-regulation of two transcription factors, cyclic AMP-responsive element binding protein-1 (CREB-1) and glucocorticoid receptor (GR). CREB-1 and GR are known to up-regulate aromatase gene expression through promoters I.3/II and I.4, respectively. We believe that these results are exciting in that they show GSE to be potentially useful in the prevention/treatment of hormone-dependent breast cancer through the inhibition of aromatase activity as well as its expression.

PMID: 16740737 [PubMed - in process]

Lesson # 1 - You will never yield an honest crop by planting stolen seeds.

"Hail to the monkey with the missing tail
this lousy edifice - just a wishing wail" ~D Sade

"And you, who runs to me for answers
You, who begs the role of shill
I taste within you accusation
Vacuum dreams left unfulfilled

But when I halt this recognition
and pack my things to rearrange
you claw at me, screeching the thunder
of one who feels betrayed" ~D Sade

"That's right, asshole - I am stronger than I've ever been.
Paltry death cannot hold me for long.
Can it be that I am stronger, even, than...me?" ~D Sade, written to Bizarro D Sade

In Ferrum Veritas


Quote
fitnecise
(@fitnecise)
New Member
Joined: 3 months ago
Posts: 1
09/09/2019 12:55 pm  

but isn't ethanol shown to increase estradiol levels?

I am the walrus


ReplyQuote
velikimajmun
(@velikimajmun)
New Member
Joined: 2 months ago
Posts: 1
09/09/2019 1:22 pm  

Grape seed extract isn't found in wine IIRC. Resveratrol on the other hand is and it is also inhibits aromatase.

Metrosexual (n); A closet homosexual not man enough to take it in the ass.


ReplyQuote
D Sade
(@d-sade)
New Member
Joined: 2 months ago
Posts: 2
09/09/2019 1:49 pm  

sorry about the misleading thread title - it was supposed to be a joke (hence the "extra seeds")

Grape Seed Extract is the compound I was discussing.

Lesson # 1 - You will never yield an honest crop by planting stolen seeds.

"Hail to the monkey with the missing tail
this lousy edifice - just a wishing wail" ~D Sade

"And you, who runs to me for answers
You, who begs the role of shill
I taste within you accusation
Vacuum dreams left unfulfilled

But when I halt this recognition
and pack my things to rearrange
you claw at me, screeching the thunder
of one who feels betrayed" ~D Sade

"That's right, asshole - I am stronger than I've ever been.
Paltry death cannot hold me for long.
Can it be that I am stronger, even, than...me?" ~D Sade, written to Bizarro D Sade

In Ferrum Veritas


ReplyQuote
Benson
(@benson)
Member Moderator
Joined: 4 months ago
Posts: 16
09/09/2019 2:06 pm  
Posted by: @D Sade
sorry about the misleading thread title - it was supposed to be a joke (hence the "extra seeds")

Grape Seed Extract is the compound I was discussing.

It gets better.

Linketylinklink

"Being smart is like being a lady, if you have to tell people you are, you aren't" - Margaret Thatcher (paraphrased)
"The tragedy of science is the slaying of a beautiful hypothesis by an ugly fact." T.H. Huxley

Quis nos es non potens ut muto, nos es postulo perfero. Illegitimis non carborundum!


ReplyQuote
virtualcyber
(@virtualcyber)
Active Member
Joined: 3 months ago
Posts: 16
09/09/2019 2:14 pm  

So far, we have hints of muscle preserving effects and fat loss effects as well.

I suppose I need to resume the experiment with resveratrol.

I wonder if BAC resveratrol will work as well as pure trans-resveratrol.

Ji-Yong David Chung


ReplyQuote
Share:

Please Login or Register