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Advanced Hypothesis, Theory & Discussion
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Topic starter
14/07/2026 8:23 am
Just wondering if any of yall have been on HRT for over 20 years? If so do you notice any negative long term side effects?
14/07/2026 8:54 am
Dont think TRT for men has been actively used for 20 years already.. correct me if I'm wrong tho.
14/07/2026 9:16 am
No I believe you are right nby. TRT is fairly new and most Dr. still dont understand the concept fully. You may find some that have been on for maybe 5-8 years, maybe.
Topic starter
14/07/2026 9:45 am
No I believe you are right nby. TRT is fairly new and most Dr. still dont understand the concept fully. You may find some that have been on for maybe 5-8 years, maybe.
Well have any of yall been on for 5+ years that have noticed long term side effects?
14/07/2026 10:08 am
Well have any of yall been on for 5+ years that have noticed long term side effects?
I'm sure you're smart enough to find the possible side effects, especially on prolonged use;
- Higher BP
- Bad cholesterol
- Prostate
- Acne
- Testicular atrophy
However all of this is different per user. TRT is an all-in package which should also monitor your health periodically, like via a blood panel.
I think a few have been on TRT for a few years, wait for them to chime in.
14/07/2026 10:35 am
3 + years... regular CBC, Chem,, LFT's, TFT's all spot on. HDL/LDL,chol, triglyceride levels are very good...my only issue is with fatigue, daytime sleepiness, "brain fog," anhedonia, that hasn't changed with TRT to the extent that I was hoping for and has actually worsened over the months.. Most likely due to mild sleep apnea(may be a side affect of TRT/AAS use) which I am currently being treated for and definitely from prior substance use > misuse > abuse history(opiates)....
Other than that I am very happy with the results...
Topic starter
14/07/2026 11:00 am
3 + years... regular CBC, Chem,, LFT's, TFT's all spot on. HDL/LDL,chol, triglyceride levels are very good...my only issue is with fatigue, daytime sleepiness, "brain fog," anhedonia, that hasn't changed with TRT to the extent that I was hoping for and has actually worsened over the months.. Most likely due to mild sleep apnea(may be a side affect of TRT/AAS use) which I am currently being treated for and definitely from prior substance use > misuse > abuse history(opiates)....
Other than that I am very happy with the results...
I seen you write in another post you were on androgel what do your levels test at on that? Possibly you have fatigue and brain fog b/c ur test levels still arent high enough?
14/07/2026 11:21 am
700 last month.. 4 pumps day, 1.62%
14/07/2026 11:43 am
Just wondering if any of yall have been on HRT for over 20 years? If so do you notice any negative long term side effects?
HRT or TRT is new. The thing I don't like about TRT, I want to fuck everyday! lol