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finasteride and aromatase inhibitors


Danimal
(@danimal)
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Joined: 4 months ago
Posts: 7
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I was doing some research on finasteride, and found this to be interesting :

Aromatase-independent Testosterone conversion into estrogenic steroids is inhibited by a 5alpha-reductase inhibitor.

Ishikawa T, Glidewell-Kenney C, Jameson JL.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Galter Pavilion, Suite 3-150, 251 E. Huron St., Chicago, Illinois 60611-2908, USA.

Estrogens are generated mainly by the action of aromatase, which converts testosterone to estradiol and androstenedione to estrone. However, in addition to estradiol and estrone, a variety of other steroids, whose synthesis is not dependent on aromatase, can stimulate the estrogen receptor. Here we show that testosterone is converted into such estrogenic steroids by aromatase-negative HeLa cells. This aromatase-independent generation of estrogenic steroids is seen in aromatase-positive MCF-7 cells as well. In both cell lines, the synthesis of estrogenic steroids was blocked by inhibition of testosterone conversion into dihydrotestosterone using a 5alpha-reductase inhibitor finasteride, suggesting that they are generated downstream of dihydrotestosterone. This finding raises the possibility that the combination of a 5alpha-reductase inhibitor and an aromatase inhibitor may reduce estrogenic steroids in vivo more completely than an aromatase inhibitor alone.


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manimal280
(@manimal280)
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Joined: 3 weeks ago
Posts: 15
 

Maybe I'll add a quarter of proscar in with the a-dex then?


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