[Sticky] First Cycle and PCT~2025

heavyiron · 2025-02-23T06:50:07Z

The effects of Testosterone One of the most common question I'm asked is "what should I do for a first cycle?" The questions are; what steroid should I take? How long should I take it? and What will the effects be? There are literally dozens of steroids available and that makes it difficult for a first time user to choose. The following information will attempt to provide enough information for a first time user to make an educated decision about anabolic androgenic steroid use. Testosterone is one of the most effective, safe and available steroids today, therefore I believe Testosterone is the best first cycle choice. The following text outlines the benefits and risks of Testosterone administration based on a clinical human trial of 61 healthy men in 2001. The purpose of the trial was to determine the dose dependency of testosterones effects on fat-free mass and muscle performance. In this trial 61 men, 18-35years old were randomized into 5 groups receiving weekly injections of 25, 50, 125, 300, 600 mg of Testosterone Enanthate for 20 weeks. They had previous weight-lifting experience and normal T levels. Their nutritional intake was standardized and they did not undertake any strength training during the trial. The only two groups that reported significant muscle building benefits were the 300 and 600 mg groups so any dose lower than 300mg will not be considered in this essay. 12 men participated in the 300 mg group and 13 men in the 600 mg group. 600mg of Testosterone a week for 20 weeks resulted in the following benefits. Increased fat free mass, muscle strength, muscle power, muscle volume, hemoglobin and IGF-1. The same 600 mg administration resulted in 2 side effects. HDL cholesterol was negatively correlated and 2 men developed acne. The normal range for total T in men is 241-827 ng/dl according to Labcorp and 260-1000 ng/dl according to Quest Laboratories. The normal range for IGF-1 is 81-225 according to Labcorp. Total T and IGF-1 levels were taken after 16 weeks and resulted in the following; Total Testosterone300 mg group-1,345 ng/dl a 691 ng increase from baseline600 mg group-2,370 ng/dl a 1,737 ng increase from baseline IGF-1 300 mg group-388 ng/dl a 74 ng increase from baseline600 mg group-304 ng/dl a 77 ng increase from baseline Body composition was measured after 20 weeks. Fat Free Mass by underwater weighing300 mg group-5.2kg (11.4lbs) increase600 mg group-7.9kg (17.38lbs) increase Fat Mass by underwater weighing300 mg group-.5kg (1.1lbs) decrease600 mg group-1.1kg (2.42lbs) decrease Thigh Muscle Volume300 mg group-84 cubic centimeter increase600 mg group-126 cubic centimeter increase Quadriceps Muscle Volume300 mg group-43 cubic centimeter increase600 mg group-68 cubic centimeter increase Leg Press Strength300 mg group-72.2kg (158.8lbs) increase 600 mg group-76.5kg (168.3lbs) increase Leg Power300 mg group-38.6 watt increase600 mg group-48.1 watt increase Hemoglobin300 mg group-6.1 gram per liter increase600 mg group-14.2 gram per liter increase Plasma HDL Cholesterol300 mg group-5.7 mg/dl decrease600 mg group-8.4 mg/dl decrease Acne300 mg group-7 of the 12 men developed acne600 mg group-2 of the 13 men developed acne There were no significant changes in PSA or liver enzymes at any dose up to 600mg. However, long-term effects of androgen administration on the prostate, cardiovascular risk, and behavior are unknown. The study demonstrated that there is a dose dependent relationship with testosterone administration. In other words the more testosterone administered the greater the muscle building effects and potential for side effects. Given the results of the study and based on years of personal experience I believe the first time user can safely use between 300-600 mg of testosterone enanthate or cypionate per week for 8-12 weeks. Because it is desirable to have even blood androgen levels I advise at least 2 equal injections per week. The following graph demonstrates that Testosterone Cypionate peaks within 1-2 days after injection and falls off to almost baseline by day 10. Therefore waiting 7 days between injections of cypionate would cause wide fluctuations in blood androgen levels. Pharmacokinetics of Testosterone cypionate Injection Source: Schulte-Beerbuhl, 1980 Figure. Pharmacokinetics of 200mg Testosterone cypionate injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag E. Fertility and Sterility 33 (1980) 201-3. If a first time user wanted to use 600 mg of cypionate or enanthate per week he would inject 300 mg on Tuesday and another 300 mg on Saturday each week for 10 weeks. When injecting long heavy esters like cypionate with this frequency I tend to have less acne then 1 injection per week. There are a number of esters which provide varying release times. Acetate or propionate esters extend the release t...

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Anabolic Steroids & Prohormones

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Cweb0909

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26/02/2025 5:16 pm

Great info laid out in a comprehensive manner for those new to aas like myself. Really appreciate the time taken to make this thread!

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