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VIGOR™ FAQ

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Robboe
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VIGOR™ FAQ

Q. What exactly is a free radical and why should I care?

A. Free radicals are molecules with unpaired electrons. Because of this structure, they are very unstable and so seek out other molecules with which they can combine to develop some sort of stability. It is when the radicals find their targets and collide that the majority of the damage is done.

Q. What damage?

A. Anything from aging, to atherosclerosis, to cancer, to recovery and growth inhibition and much more equally harmful stuff.

Q. What causes free radicals?

A. As stated in the product write-up, “There are numerous origins of free radical formation including pollution in the air, drug use, chemicals in the food and drink we consume, pesticides and contaminants on crops and even exercise (as waste products of cellular respiration).”

Q. Will I notice a difference straight away when I use VIGOR™?

A. It is not something you will “feel” per se, but if you currently don’t consume enough fruit and vegetables (which most people simply don’t), then over time you will notice a mildly reduced recovery time and even a mild increase in the rate of gains. Health-wise you will feel like a million dollars.

Q. Where can I buy the product?

A. Check our retailers section.

Q. How many servings per bottle?

A. Based on a two capsules per day usage, each bottle, containing 60 capsules, would last 30 days.

Q. Should I cycle VIGOR™?

A. Normally for Designer Supplements or Designer Stackables products we recommend you cycle all supplements except for multivitamins and minerals, protein powder and anti-oxidants. Given that VIGOR™ caters for the anti-oxidant aspect, it can and should be run year-round.

Q. The label says “ORAC” and “µmolesTE”. What do these terms mean?

A. ORAC stands for Oxygen Radical Absorption Capacity, which, in layman’s, measures the anti-oxidant activity of a substance or compound. Generally speaking, the higher the ORAC value the better.

“µmolesTE” is shorthand for micromoles/trolox equivalents. Without making it too confusing, it’s basically a method of standardizing ORAC.

Q. So is 5800 ORAC µmolesTE good?

A. The USDA recommends the average adult gets about 3000-5000 ORAC units per day, so yeah, it is pretty superb.

Q. I already consume fruit with breakfast and vegetables with my evening meal, so do I still need VIGOR™?

A. Absolutely. While you have a good base, those portions alone will not be enough to supply you with enough ORAC units.

Q. What dose of VIGOR™ do you recommend for me?

A. At least two caps per day, even if you do consume 2-3 portions of fruit and vegetables per day already. Space them out over breakfast and post-workout if you like.

Q. Why post-workout?

A. Because after a strenuous workout, oxidative stress is often at its worst due to the increased cellular respiration from training. At this time, the body can either begin the recuperation phases of recovery that eventually lead to growth and strength, or further tissue damage can occur if the body is not prepared for the attack. Using VIGOR™ at this time helps prime your cells towards recovery and growth.

Q. Is VIGOR™ ok for vegetarians?

A. Yes. But vegans must beware that the capsules are gelatin-based.

Q. There is a warning in the write-up about using VIGOR™ with stimulants. What does this mean?

A. Your body has a means of metabolizing drugs and toxins, through a collection of various enzymes. Certain extracts present in VIGOR™ can inhibit these enzymes, thereby delaying the rate at which your body can process compounds like stimulants etc. The extract content of VIGOR™ is not hugely significant to cause any major issue, but those more sensitive to stimulants and such may feel slightly more uncomfortable combining the two. If you give it 90 minutes or so after taking VIGOR™, the use of stimulants will be fine.

Q. What about any particular health conditions?

A. Always check with your doctor before using any supplements.

Full write-up in PDF format is attached.


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Dio
 Dio
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I will read this when the text is left-aligned, as it should be.

Be brave. Always be brave.


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Douche_Nutz
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Posted by: @Dio
I will read this when the text is left-aligned, as it should be.

Robboe, looking for any testers?


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rippedforce63
(@rippedforce63)
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Oh I'll definetly be picking this up once it hits the market, even though I try and get a few serving of fruit and vegetables in during the day I always end up feeling like I might be depriving myself of vital nutrients. I like were DS is going with this product, many of us who adhere to the bodybuilding lifestyle often overlook the simple addage of eating your fruits and veggies so its nice to see a company come out with a product that is geared more towards overall well being instead of an ergogenic or fatloss aid.


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ScottL
(@scottl)
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Good stuff Rob.

Tell them they should add blueberry...extract/whatever to the next revision. I've been looking for something like this. Strawberry (elagalic acid) would be good too.


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Jason Pegg
(@jason-pegg)
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Good stuff guys, gonna give it a whirl, for COX-2 inhibition if nothing else...my elbow is killing me.

Jason


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ersatz
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Posted by: @ScottL
Good stuff Rob.

Tell them they should add blueberry...extract/whatever to the next revision. I've been looking for something like this. Strawberry (elagalic acid) would be good too.

Ellagic acid is found in strawberries and raspberries so it's covered in Vigor.
Billberry is a blueberry so it's also covered in the product. Would be nice to see Idebenone in there and perhaps some oral SOD(gliSODin) but Vigor should be good enough.

I think that Vit C & E should have been excluded as most people get enough from a multi-vit. Grape Seed Extract(GSE), ellagic acid, and the aoxs in bilberry should be dosed at 50mg each though I personally use 100mg-200mg. Exclusion of the vits would allow for 50mg dosages if not 100mgs of each which would be more than sufficient. Plus they could then add 100mg of Idebenone and be hands down the best aox product available.


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ersatz
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Oh and where are the vegetable extracts, like broccoli?


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liorrh
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that patented plant fruit excract company is relay starting to make a penny or two.
the supplement looks good. I would time it in the meal and last meal.
there is evidence about antioxdants post inflammation bouts actually worsening free radical state.


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Robboe
(@robboe)
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Posted by: @liorrh
there is evidence about antioxdants post inflammation bouts actually worsening free radical state.

Do share.

Posted by: @rippedforce63
Oh I'll definetly be picking this up once it hits the market, even though I try and get a few serving of fruit and vegetables in during the day I always end up feeling like I might be depriving myself of vital nutrients. I like were DS is going with this product, many of us who adhere to the bodybuilding lifestyle often overlook the simple addage of eating your fruits and veggies so its nice to see a company come out with a product that is geared more towards overall well being instead of an ergogenic or fatloss aid.

We try to avoid releasing products that cannot all be stacked.

I've recently noticed one particular company have like 3 products that all do essentially the same thing.


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trouble
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Lipid peroxidation and antioxidant status in adults receiving lipid- based home parenteral nutrition. American Journal of Clinical Nutrition 68: 888-893 (1998).

BACKGROUND: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese- dependent enzyme), selenium-dependent glutathione peroxidase (Se- GSHPx), and alpha-tocopherol. OBJECTIVE: We investigated lipid peroxidation and antioxidant status in patients receiving home parenteral nutrition (HPN) providing variable amounts of a lipid emulsion rich in PUFAs, and alpha-tocopherol, zinc, copper, and manganese as recommended by the American Medical Association, and no selenium. DESIGN: Serum malondialdehyde, plasma alpha-tocopherol, selenium, Se-GSHPx, PUFAs, and red blood cell Se-GSHPx and SOD were evaluated in 12 patients and in 25 healthy control subjects. Malondialdehyde was also assessed in a group of 40 healthy control subjects. RESULTS: Patients had significantly higher concentrations of malondialdehyde and SOD and lower alpha-tocopherol concentrations and selenium nutritional status. Linear regression analysis showed that malondialdehyde was associated with the daily PUFA load (r=0.69, P< 0.03) and with plasma alpha-tocopherol (r=-0.59, P< 0.05), but stepwise multiple regression analysis confirmed only the association between malondialdehyde and alpha-tocopherol; plasma alpha-tocopherol was associated with the daily PUFA load (r=-0.65, P< 0.04) and with the duration of HPN (r=-0.74, P< 0.02). CONCLUSIONS: In HPN patients, the peroxidative stress due to lipid emulsions rich in PUFAs is counteracted primarily by alpha-tocopherol. The dosages of alpha- tocopherol, zinc, copper, and manganese recommended by the American Medical Association appear sufficient to sustain SOD activity but inadequate to maintain alpha-tocopherol nutritional status. HPN formulations should be supplemented with selenium.

See also: http://www.mcmaster.ca/inabis98/pharmtox/arend0843/two.html

Many, many other articles describe lipid peroxidation by PUFAs (n-3 and n-6) and the redox couples necessary to limit this reaction extent and damage in PUFA supplemented individual with periodic elevation of ROS via exertion or other forms of oxidative stress spikes (infection, acute and elevated chronic stress loads, thermal and osmotic stress, etc.).


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Kimbo
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Posted by: @liorrh
that patented plant fruit excract company is relay starting to make a penny or two.
the supplement looks good. I would time it in the meal and last meal.
there is evidence about antioxdants post inflammation bouts actually worsening free radical state.

It was my understanding that some antioxidants might act as pro-oxidants if used pre-exercise.

If someone says something about you, and it really bothers you, it's probably because it's true.


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liorrh
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Posted by: @kimboinatl
It was my understanding that some antioxidants might act as pro-oxidants if used pre-exercise.

I've seen only evidence otherwise, at least talking about common antioxidants. happy to learn what you are tlaking about.

a look at NAC, C for instance will tell you that they are better off before the bout of inflammation promoting damage occurs.


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ScottL
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Posted by: @liorrh
I've seen only evidence otherwise, at least talking about common antioxidants. happy to learn what you are tlaking about.

a look at NAC, C for instance will tell you that they are better off before the bout of inflammation promoting damage occurs.

he's probably talking about that "famous" abstract where I think vit C and/or NAC taken prior to exercise increased the damage. If you can find the thread where spook asked us what we wanted him to write about (perhaps he can get around to some of those now BTW) I posted it there.


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trouble
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Posted by: @ScottL
he's probably talking about that "famous" abstract where I think vit C and/or NAC taken prior to exercise increased the damage.

Didn't the use of NAC after drinking show an increase in liver damage?

If it casued damage before ROS were present, that might suggest it should not be used as supplement for daily consumption...

The point is, you need the entire redox couple (and NAC forms a couple with more than one compound for its regeneration as a reducing agent) to maintain it in a protective state.


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